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M9490488.TXT
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1994-09-19
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Document 0488
DOCN M9490488
TI Ablation of neoplasia by direct current.
DT 9411
AU Taylor TV; Engler P; Pullan BR; Holt S; Baylor College of Medicine,
Houston, Texas.
SO Br J Cancer. 1994 Aug;70(2):342-5. Unique Identifier : AIDSLINE
MED/94331325
AB The application of low-voltage direct electrical current (DEC) has been
studied in animals and humans for the ablation of anal condylomata,
oesophageal cancer and Kaposi's sarcoma. Twenty milliamps of DEC passed
through multiple 6 cm x 1 cm, flat-plate longitudinal electrodes into
the squamous mucosa of the oesophagus of healthy dogs for periods
ranging from 10 min to 2 h resulted in denudation and necrosis of the
oesophageal mucosa at the site of application of the current. In humans,
the application of DEC to two patients with benign anal condyloma
acuminata, three patients with inoperable obstructing oesophageal cancer
and one patient with disseminated Kaposi sarcoma resulted in striking
necrosis of tumour tissue that was confirmed by macroscopic and
microscopic studies. These initial findings imply promising therapeutic
potential for the use of DEC as a simple, effective, safe, low-cost
alternative for ablation of neoplasia.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS/THERAPY
Adenocarcinoma/THERAPY Adult Aged Aged, 80 and over Animal Anus
Diseases/THERAPY Carcinoma, Squamous Cell/THERAPY Case Report
Condylomata Acuminata/THERAPY Dogs *Electric Stimulation Therapy
Esophageal Neoplasms/THERAPY Female Human Male Middle Age
Neoplasms/*THERAPY Neoplasms, Experimental/*THERAPY Sarcoma,
Kaposi's/COMPLICATIONS/THERAPY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).